| ARCH Venture Management, LLC |
| 4.14% | 9.62% | #2 | $4,552.5万 | 324.7万股 | $6,513.8万 | 324.7万股 | 00.00% | 持仓不变 |
| GSK plc |
| 3.53% | 5.06% | #3 | $2,125.3万 | 151.3万股 | $3,034.4万 | 151.3万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $1,105.4万 | 78.7万股 | $1,440.6万 | 71.8万股 | +6.9万股+9.55% | 加仓 |
| Orland Properties Ltd |
| 5.25% | 5.67% | #1 | $1,060.4万 | 75.5万股 | $1,513.9万 | 75.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #50 | $1,017.7万 | 72.4万股 | $384.8万 | 19.2万股 | +53.3万股+277.62% | 加仓 |
| Decheng Capital LLC |
| 1.33% | 2.1% | #6 | $972.3万 | 69.2万股 | $1,388.3万 | 69.2万股 | 00.00% | 持仓不变 |
| Almitas Capital LLC |
| 1.9% | 2.62% | #4 | $816.9万 | 58.1万股 | $1,159.1万 | 57.8万股 | +3,600股+0.62% | 加仓 |
| Foresite Capital Management V, LLC |
| 1.85% | 3.53% | #5 | $669.3万 | 47.6万股 | $957.0万 | 47.7万股 | -692股-0.15% | 减仓 |
| Alphabet公司Alphabet Inc. |
| 0.14% | 0.15% | #12 | $588.3万 | 29.3万股 | $588.3万 | 29.3万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $516.3万 | 36.7万股 | $920.6万 | 45.9万股 | -9.1万股-19.92% | 减仓 |
| Opaleye Management Inc. |
| 0.44% | 0.21% | #9 | $483.4万 | 34.4万股 | $158.7万 | 7.9万股 | +26.5万股+334.94% | 加仓 |
| venBio Partners LLC |
| 0.91% | 2.41% | #7 | $474.5万 | 33.8万股 | $677.4万 | 33.8万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $436.6万 | 31.1万股 | $335.2万 | 16.7万股 | +14.4万股+86.03% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #54 | $260.4万 | 18.5万股 | $145.5万 | 7.3万股 | +11.3万股+155.54% | 加仓 |
| HSG Holding Ltd |
| 0.18% | <0.01% | #11 | $214.0万 | 15.2万股 | $7.3万 | 15.2万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #21 | $182.9万 | 13.0万股 | $233.5万 | 11.6万股 | +1.4万股+11.84% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $166.5万 | 11.9万股 | $60.7万 | 3.0万股 | +8.8万股+291.35% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #24 | $155.3万 | 11.1万股 | $110.6万 | 5.5万股 | +5.5万股+100.56% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #45 | $151.1万 | 10.8万股 | $172.5万 | 8.6万股 | +2.2万股+25.12% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #25 | $149.4万 | 10.6万股 | $297.9万 | 14.9万股 | -4.2万股-28.43% | 减仓 |
| Velan Capital Investment Management LP |
| 0.9% | 1.28% | #8 | $147.5万 | 10.5万股 | $204.6万 | 10.2万股 | +3,000股+2.94% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #40 | $130.8万 | 9.3万股 | $174.4万 | 8.7万股 | +6,170股+7.10% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #58 | $129.1万 | 9.2万股 | $46.2万 | 2.3万股 | +6.9万股+299.27% | 加仓 |
| MIC Capital Management UK LLP |
| 0.31% | 0.5% | #10 | $122.3万 | 8.7万股 | $174.6万 | 8.7万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #52 | $121.9万 | 8.7万股 | $229.7万 | 11.4万股 | -2.8万股-24.20% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #47 | $95.7万 | 6.8万股 | $95.9万 | 4.8万股 | +2.0万股+42.66% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #26 | $83.9万 | 6.0万股 | $0 | 0股 | +6.0万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $75.3万 | 5.4万股 | $789.3万 | 39.3万股 | -34.0万股-86.38% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #31 | $74.4万 | 5.3万股 | $23.2万 | 1.2万股 | +4.1万股+356.86% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #60 | $64.6万 | 4.6万股 | $128.2万 | 6.4万股 | -1.8万股-27.99% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #29 | $59.5万 | 4.2万股 | $38.7万 | 1.9万股 | +2.3万股+119.35% | 加仓 |
| Ikarian Capital, LLC |
| 0.06% | 0.07% | #14 | $57.7万 | 4.1万股 | $82.4万 | 4.1万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #64 | $56.3万 | 4.0万股 | $622.3万 | 31.0万股 | -27.0万股-87.07% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #69 | $52.1万 | 3.7万股 | $60.1万 | 3.7万股 | +30股+0.08% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #28 | $51.4万 | 3.7万股 | $0 | 0股 | +3.7万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #65 | $43.1万 | 3.1万股 | $26.4万 | 1.3万股 | +1.8万股+133.52% | 加仓 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #43 | $41.3万 | 2.9万股 | $59.0万 | 2.9万股 | 00.00% | 持仓不变 |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | — | #15 | $36.8万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #36 | $36.6万 | 2.6万股 | $42.7万 | 2.1万股 | +4,788股+22.49% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #62 | $36.5万 | 2.6万股 | $63.8万 | 3.2万股 | -5,832股-18.33% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #59 | $34.7万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #49 | $34.5万 | 2.5万股 | $32.0万 | 1.6万股 | +8,569股+53.65% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | 0.01% | #22 | $30.8万 | 2.2万股 | $40.4万 | 2.0万股 | +1,833股+9.11% | 加仓 |
| Clearstead顾问Clearstead Advisors, LLC |
| <0.01% | 0.01% | #20 | $28.0万 | 2.0万股 | $80.1万 | 4.0万股 | -2.0万股-50.00% | 减仓 |
| EntryPoint Capital, LLC |
| 0.07% | — | #13 | $27.3万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #16 | $25.3万 | 1.8万股 | $36.1万 | 1.8万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| <0.01% | 0.01% | #17 | $25.1万 | 1.8万股 | $41.7万 | 2.1万股 | -2,925股-14.06% | 减仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| <0.01% | — | #38 | $22.7万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #48 | $21.7万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #75 | $19.5万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
