| 贝莱德BlackRock, Inc. |
| 0.02% | 0.02% | #112 | $12.64亿 | 1,030.8万股 | $10.31亿 | 977.9万股 | +52.8万股+5.40% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 3.59% | 3.81% | #8 | $7.78亿 | 634.9万股 | $6.69亿 | 634.9万股 | 00.00% | 持仓不变 |
| RTW投资RTW INVESTMENTS, LP |
| 5.3% | 5.31% | #4 | $6.20亿 | 506.1万股 | $5.33亿 | 505.9万股 | +2,122股+0.04% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | — | #106 | $4.45亿 | 362.9万股 | $0 | 0股 | +362.9万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.07% | #66 | $4.19亿 | 341.7万股 | $3.79亿 | 360.0万股 | -18.3万股-5.08% | 减仓 |
| 瑞银集团UBS Group AG |
| 0.05% | 0.08% | #74 | $4.17亿 | 339.9万股 | $5.46亿 | 517.8万股 | -177.9万股-34.35% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #132 | $4.07亿 | 332.2万股 | $3.29亿 | 311.7万股 | +20.5万股+6.57% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | — | #166 | $3.50亿 | 285.3万股 | $0 | 0股 | +285.3万股 | 新买入 |
| JOHNSON & JOHNSON |
| 37.59% | 39.57% | #1 | $3.00亿 | 244.9万股 | $2.58亿 | 244.9万股 | 00.00% | 持仓不变 |
| 景顺Invesco Ltd. |
| 0.02% | 0.03% | #100 | $2.87亿 | 234.1万股 | $2.28亿 | 216.5万股 | +17.6万股+8.13% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #94 | $2.64亿 | 215.0万股 | $1.76亿 | 166.5万股 | +48.4万股+29.07% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.11% | — | #54 | $2.61亿 | 213.0万股 | $0 | 0股 | +213.0万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #135 | $2.13亿 | 174.1万股 | $1.76亿 | 166.9万股 | +7.2万股+4.30% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.54% | 0.56% | #25 | $1.73亿 | 141.4万股 | $1.49亿 | 141.4万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #142 | $1.62亿 | 132.4万股 | $1.37亿 | 129.5万股 | +2.9万股+2.24% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.08% | 0.08% | #62 | $1.41亿 | 115.2万股 | $1.13亿 | 107.2万股 | +8.0万股+7.43% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.81% | 2.54% | #13 | $1.20亿 | 98.2万股 | $1.30亿 | 123.1万股 | -24.9万股-20.23% | 减仓 |
| ADAR1 Capital Management, LLC |
| 5.43% | 6.17% | #3 | $1.18亿 | 96.1万股 | $1.05亿 | 99.4万股 | -3.3万股-3.35% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #185 | $1.11亿 | 90.6万股 | $5,104.2万 | 76.8万股 | +13.8万股+17.91% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.28% | 0.18% | #40 | $1.09亿 | 88.9万股 | $6,252.3万 | 59.3万股 | +29.6万股+49.92% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.78% | 0.88% | #22 | $1.08亿 | 88.3万股 | $8,740.7万 | 82.9万股 | +5.3万股+6.45% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #154 | $9,963.9万 | 81.3万股 | $8,210.1万 | 77.9万股 | +3.4万股+4.35% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.52% | 0.56% | #26 | $8,961.2万 | 73.1万股 | $7,598.6万 | 72.1万股 | +1.0万股+1.40% | 加仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.07% | 0.06% | #64 | $8,891.2万 | 72.5万股 | $6,554.0万 | 62.2万股 | +10.4万股+16.65% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #215 | $8,239.7万 | 67.2万股 | $6,977.4万 | 66.2万股 | +1.0万股+1.54% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #148 | $8,165.1万 | 66.6万股 | $6,197.2万 | 58.8万股 | +7.8万股+13.29% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.03% | 0.03% | #85 | $7,337.7万 | 59.9万股 | $5,663.4万 | 53.7万股 | +6.1万股+11.40% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #147 | $7,155.9万 | 58.4万股 | $5,828.2万 | 55.3万股 | +3.1万股+5.57% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.06% | 0.05% | #70 | $7,006.9万 | 57.2万股 | $4,789.2万 | 45.4万股 | +11.7万股+25.80% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.07% | 0.06% | #67 | $6,962.4万 | 56.8万股 | $6,124.6万 | 58.1万股 | -1.3万股-2.25% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #130 | $6,374.6万 | 52.0万股 | $1,453.2万 | 13.8万股 | +38.2万股+277.19% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | — | #133 | $5,365.9万 | 43.8万股 | $0 | 0股 | +43.8万股 | 新买入 |
| LORD, ABBETT & CO. LLC |
| 0.14% | 0.06% | #50 | $4,890.9万 | 39.9万股 | $1,722.9万 | 16.3万股 | +23.6万股+144.09% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.02% | 0.02% | #99 | $4,722.5万 | 38.5万股 | $3,876.8万 | 36.8万股 | +1.7万股+4.74% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | 0.01% | #170 | $4,392.0万 | 35.8万股 | $3,599.0万 | 34.1万股 | +1.7万股+4.93% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.2% | 0.08% | #44 | $4,373.7万 | 35.7万股 | $1,439.8万 | 13.7万股 | +22.0万股+161.20% | 加仓 |
| 纽伯格伯曼集团Neuberger Berman Group LLC |
| 0.02% | 0.01% | #96 | $3,707.2万 | 30.2万股 | $1,490.8万 | 14.1万股 | +16.1万股+113.82% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #117 | $3,695.4万 | 30.1万股 | $2,050.3万 | 19.5万股 | +10.7万股+54.97% | 加仓 |
| 683 Capital Management, LLC |
| 1.75% | 2.04% | #14 | $3,554.8万 | 29.0万股 | $3,900.9万 | 37.0万股 | -8.0万股-21.64% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #157 | $3,482.3万 | 28.4万股 | $1,348.2万 | 12.8万股 | +15.6万股+122.09% | 加仓 |
| 斯蒂芬斯投资管理Stephens Investment Management Group LLC |
| 0.37% | — | #32 | $3,454.7万 | 28.2万股 | $0 | 0股 | +28.2万股 | 新买入 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #86 | $3,186.7万 | 26.0万股 | $0 | 0股 | +26.0万股 | 新买入 |
| Eagle Health Investments LP |
| 5.05% | 3.31% | #5 | $3,043.9万 | 24.8万股 | $1,890.1万 | 17.9万股 | +6.9万股+38.48% | 加仓 |
| NEXTBio Capital Management LP |
| 12.37% | 11.24% | #2 | $2,688.6万 | 21.9万股 | $2,420.2万 | 23.0万股 | -1.0万股-4.48% | 减仓 |
| 西格尔·布莱恩特·哈米尔SEGALL BRYANT & HAMILL, LLC |
| 0.31% | 0.32% | #33 | $2,632.1万 | 21.5万股 | $2,242.0万 | 21.3万股 | +2,010股+0.94% | 加仓 |
| SEB资产管理SEB Asset Management AB |
| 0.1% | 0.1% | #56 | $2,573.7万 | 21.0万股 | $2,449.7万 | 23.2万股 | -2.2万股-9.66% | 减仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 0.49% | 0.5% | #28 | $2,560.7万 | 20.9万股 | $1,683.2万 | 16.0万股 | +4.9万股+30.81% | 加仓 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.07% | 0.07% | #68 | $2,545.8万 | 20.8万股 | $2,216.4万 | 21.0万股 | -2,592股-1.23% | 减仓 |
| 花旗集团CITIGROUP INC |
| 0.01% | 0.01% | #161 | $2,435.3万 | 19.9万股 | $1,672.8万 | 15.9万股 | +4.0万股+25.18% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.44% | 0.09% | #30 | $2,354.8万 | 19.2万股 | $443.7万 | 4.2万股 | +15.0万股+356.29% | 加仓 |
