| 木星资产管理Jupiter Topco LLC |
| 0.47% | — | #40 | $11.46亿 | 342.1万股 | $0 | 0股 | +342.1万股 | 新买入 |
| 富达投资FMR LLC |
| 0.03% | 0.04% | #100 | $7.76亿 | 231.7万股 | $6.96亿 | 216.1万股 | +15.6万股+7.22% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #141 | $7.68亿 | 229.3万股 | $7.49亿 | 232.5万股 | -3.2万股-1.39% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 10.23% | 12.82% | #6 | $6.82亿 | 203.6万股 | $6.56亿 | 203.6万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 2.94% | 3.24% | #17 | $5.87亿 | 175.3万股 | $5.65亿 | 175.3万股 | 00.00% | 持仓不变 |
| Orbis Allan GrayOrbis Allan Gray Ltd |
| 1.76% | 3.36% | #25 | $5.12亿 | 153.0万股 | $7.97亿 | 247.2万股 | -94.3万股-38.13% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.01% | #116 | $4.47亿 | 133.5万股 | $2.44亿 | 75.7万股 | +57.8万股+76.44% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #153 | $4.14亿 | 123.5万股 | $3.94亿 | 122.2万股 | +1.3万股+1.09% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #146 | $3.44亿 | 102.6万股 | $2.85亿 | 88.4万股 | +14.2万股+16.08% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.48% | 0.41% | #39 | $3.40亿 | 101.5万股 | $2.63亿 | 81.6万股 | +20.0万股+24.49% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 3.36% | 3.66% | #14 | $3.23亿 | 96.3万股 | $3.10亿 | 96.3万股 | 00.00% | 持仓不变 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.86% | 2.25% | #22 | $3.21亿 | 95.9万股 | $3.06亿 | 94.9万股 | +9,823股+1.03% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #102 | $3.16亿 | 94.3万股 | $2.03亿 | 63.1万股 | +31.2万股+49.48% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.02% | <0.01% | #129 | $2.86亿 | 85.4万股 | $3,410.5万 | 64.3万股 | +21.1万股+32.73% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #132 | $2.50亿 | 74.8万股 | $2.10亿 | 65.1万股 | +9.7万股+14.92% | 加仓 |
| Cormorant Asset Management, LP |
| 10.88% | 14.33% | #4 | $2.14亿 | 64.0万股 | $2.85亿 | 88.6万股 | -24.6万股-27.72% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.02% | 0.03% | #126 | $1.84亿 | 54.9万股 | $2.29亿 | 71.1万股 | -16.2万股-22.78% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #138 | $1.83亿 | 54.7万股 | $1.72亿 | 53.5万股 | +1.2万股+2.31% | 加仓 |
| 景顺Invesco Ltd. |
| 0.01% | <0.01% | #130 | $1.80亿 | 53.8万股 | $1,978.1万 | 6.1万股 | +47.6万股+775.53% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 1.03% | 1.16% | #32 | $1.42亿 | 42.5万股 | $1.16亿 | 35.9万股 | +6.7万股+18.56% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | <0.01% | #140 | $1.16亿 | 34.7万股 | $318.9万 | 8.4万股 | +26.3万股+312.08% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #111 | $1.10亿 | 32.7万股 | $8,896.4万 | 27.6万股 | +5.1万股+18.47% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.09% | 0.1% | #72 | $9,803.5万 | 29.2万股 | $9,142.8万 | 28.7万股 | +5,045股+1.76% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.22% | — | #53 | $9,345.0万 | 27.9万股 | $0 | 0股 | +27.9万股 | 新买入 |
| Vivo Capital, LLC |
| 8.29% | 9.08% | #8 | $9,076.7万 | 27.1万股 | $1.09亿 | 33.9万股 | -6.8万股-20.00% | 减仓 |
| Logos Global Management LP |
| 3.75% | 4.58% | #13 | $8,704.5万 | 26.0万股 | $9,182.4万 | 28.5万股 | -2.5万股-8.77% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #151 | $8,064.7万 | 24.1万股 | $7,343.8万 | 22.8万股 | +1.3万股+5.68% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.04% | 0.02% | #99 | $7,945.2万 | 23.7万股 | $4,132.3万 | 12.8万股 | +10.9万股+85.04% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.45% | 1.1% | #26 | $7,703.5万 | 23.0万股 | $5,557.8万 | 17.3万股 | +5.8万股+33.39% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.35% | 0.39% | #45 | $7,526.1万 | 22.5万股 | $6,733.8万 | 20.9万股 | +1.6万股+7.56% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #148 | $7,365.6万 | 22.0万股 | $6,941.5万 | 21.5万股 | +4,561股+2.12% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.24% | <0.01% | #50 | $7,328.5万 | 21.9万股 | $21.3万 | 662股 | +21.8万股+32,966.16% | 加仓 |
| Verition基金管理Verition Fund Management LLC |
| 0.09% | — | #75 | $6,732.6万 | 20.1万股 | $0 | 0股 | +20.1万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.21% | 0.24% | #56 | $6,696.2万 | 20.0万股 | $6,444.2万 | 20.0万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #185 | $6,642.0万 | 19.8万股 | $4,643.3万 | 14.4万股 | +5.4万股+37.66% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.02% | #103 | $6,307.7万 | 18.8万股 | $4,610.0万 | 14.3万股 | +4.5万股+31.68% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #131 | $6,299.4万 | 18.8万股 | $5,474.1万 | 17.0万股 | +1.8万股+10.75% | 加仓 |
| Affinity Asset Advisors, LLC |
| 2.8% | 2.83% | #18 | $6,193.6万 | 18.5万股 | $5,477.2万 | 17.0万股 | +1.5万股+8.82% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 2.05% | 4.31% | #21 | $5,943.1万 | 17.8万股 | $1.06亿 | 33.1万股 | -15.3万股-46.29% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.08% | 0.09% | #81 | $5,570.9万 | 16.6万股 | $5,557.3万 | 17.2万股 | -6,085股-3.53% | 减仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.04% | #98 | $5,372.6万 | 16.0万股 | $5,646.0万 | 17.5万股 | -1.5万股-8.42% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.05% | 0.05% | #93 | $5,104.7万 | 15.2万股 | $4,131.4万 | 12.8万股 | +2.4万股+18.91% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.04% | 0.01% | #96 | $4,586.9万 | 13.7万股 | $1,454.7万 | 4.5万股 | +9.2万股+203.46% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #183 | $4,387.3万 | 13.1万股 | $3,494.0万 | 10.8万股 | +2.3万股+20.84% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #170 | $4,213.9万 | 12.6万股 | $5,617.4万 | 17.4万股 | -4.8万股-27.81% | 减仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.04% | 0.01% | #97 | $4,092.0万 | 12.2万股 | $906.4万 | 2.8万股 | +9.4万股+334.45% | 加仓 |
| 683 Capital Management, LLC |
| 1.82% | 1.9% | #23 | $3,696.1万 | 11.0万股 | $3,631.1万 | 11.3万股 | -2,300股-2.04% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #155 | $3,616.8万 | 10.8万股 | $2,321.2万 | 7.2万股 | +3.6万股+49.95% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | <0.01% | #137 | $3,595.9万 | 10.7万股 | $238.0万 | 7,388股 | +10.0万股+1,353.83% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.11% | — | #30 | $3,347.9万 | 10.0万股 | $0 | 0股 | +10.0万股 | 新买入 |
