| 贝莱德BlackRock, Inc. |
| 0.02% | 0.02% | #132 | $15.32亿 | 2,923.6万股 | $10.01亿 | 2,831.4万股 | +92.1万股+3.25% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 2.63% | 2.03% | #11 | $5.25亿 | 1,001.2万股 | $3.54亿 | 1,001.2万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #133 | $4.97亿 | 949.1万股 | $3.36亿 | 951.1万股 | -2.0万股-0.21% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #157 | $4.80亿 | 916.1万股 | $3.35亿 | 946.5万股 | -30.5万股-3.22% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #197 | $3.94亿 | 751.5万股 | $2.63亿 | 742.7万股 | +8.8万股+1.18% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #115 | $3.53亿 | 673.7万股 | $1.65亿 | 466.5万股 | +207.3万股+44.44% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.47% | 0.34% | #39 | $3.39亿 | 646.1万股 | $2.18亿 | 616.0万股 | +30.1万股+4.88% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #163 | $2.35亿 | 447.8万股 | $1.48亿 | 418.2万股 | +29.6万股+7.07% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.04% | 0.03% | #106 | $2.20亿 | 419.5万股 | $1.60亿 | 452.2万股 | -32.8万股-7.24% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 3.05% | 2.07% | #8 | $2.10亿 | 400.0万股 | $1.27亿 | 359.0万股 | +41.0万股+11.41% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.09% | 0.11% | #72 | $2.07亿 | 395.4万股 | $2.15亿 | 607.2万股 | -211.8万股-34.88% | 减仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.47% | 0.2% | #38 | $2.07亿 | 395.1万股 | $8,194.1万 | 231.7万股 | +163.4万股+70.52% | 加仓 |
| Commodore Capital LP |
| 9.36% | 8.59% | #1 | $1.57亿 | 300.0万股 | $1.49亿 | 420.0万股 | -120.0万股-28.57% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #127 | $1.47亿 | 281.5万股 | $1.05亿 | 297.0万股 | -15.5万股-5.23% | 减仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.08% | 0.07% | #78 | $1.32亿 | 252.9万股 | $8,981.4万 | 254.0万股 | -1.1万股-0.45% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.07% | 0.08% | #80 | $1.27亿 | 242.1万股 | $1.05亿 | 296.9万股 | -54.8万股-18.45% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.01% | #147 | $1.22亿 | 233.5万股 | $7,909.2万 | 223.7万股 | +9.8万股+4.40% | 加仓 |
| 纽文Nuveen, LLC |
| 0.03% | 0.02% | #119 | $1.22亿 | 232.4万股 | $8,700.6万 | 246.1万股 | -13.6万股-5.54% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | 0.01% | #169 | $1.13亿 | 215.7万股 | $6,328.4万 | 191.7万股 | +24.0万股+12.54% | 加仓 |
| BVF INC/IL |
| 2.89% | 2.25% | #10 | $1.13亿 | 215.5万股 | $7,072.0万 | 200.0万股 | +15.5万股+7.74% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #187 | $1.06亿 | 202.4万股 | $6,655.4万 | 188.2万股 | +14.2万股+7.53% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 6.04% | 1.95% | #2 | $1.02亿 | 193.8万股 | $2,157.0万 | 61.0万股 | +132.8万股+217.69% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #167 | $9,912.6万 | 189.2万股 | $8,243.4万 | 233.1万股 | -43.9万股-18.85% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #170 | $9,596.8万 | 183.2万股 | $6,000.9万 | 169.7万股 | +13.5万股+7.93% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #238 | $9,179.0万 | 175.2万股 | $4,654.5万 | 155.1万股 | +20.0万股+12.92% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.75% | 0.59% | #29 | $8,762.3万 | 167.2万股 | $5,913.5万 | 167.2万股 | 00.00% | 持仓不变 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.1% | 0.08% | #69 | $8,307.3万 | 158.6万股 | $6,310.3万 | 178.5万股 | -19.9万股-11.15% | 减仓 |
| Affinity Asset Advisors, LLC |
| 3.26% | 2.47% | #7 | $7,204.3万 | 137.5万股 | $4,773.6万 | 135.0万股 | +2.5万股+1.85% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.1% | — | #70 | $7,167.6万 | 136.8万股 | $0 | 0股 | +136.8万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.03% | 0.02% | #117 | $6,874.4万 | 131.2万股 | $2,511.6万 | 71.0万股 | +60.2万股+84.72% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.38% | 0.21% | #42 | $6,490.7万 | 123.9万股 | $2,800.4万 | 79.2万股 | +44.7万股+56.42% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #159 | $6,171.8万 | 117.8万股 | $3,993.0万 | 112.9万股 | +4.9万股+4.31% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #162 | $6,131.5万 | 117.0万股 | $645.4万 | 18.3万股 | +98.8万股+541.11% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.06% | — | #88 | $6,073.7万 | 115.9万股 | $0 | 0股 | +115.9万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #277 | $5,943.7万 | 113.4万股 | $4,680.8万 | 132.4万股 | -18.9万股-14.30% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | 0.01% | #185 | $5,749.2万 | 109.7万股 | $3,664.9万 | 103.6万股 | +6.1万股+5.87% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.02% | #110 | $5,716.0万 | 109.1万股 | $3,162.2万 | 89.4万股 | +19.7万股+21.99% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.04% | 0.02% | #107 | $5,440.2万 | 103.8万股 | $2,760.5万 | 78.1万股 | +25.8万股+33.00% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.86% | 2.82% | #15 | $5,392.8万 | 102.9万股 | $6,969.0万 | 197.1万股 | -94.2万股-47.78% | 减仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.03% | 0.02% | #128 | $5,154.7万 | 98.4万股 | $3,387.5万 | 95.8万股 | +2.6万股+2.69% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.04% | 0.04% | #105 | $5,082.6万 | 97.0万股 | $3,533.6万 | 99.9万股 | -2.9万股-2.94% | 减仓 |
| 峰会合伙人公共资产SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 0.88% | — | #26 | $4,978.8万 | 95.0万股 | $0 | 0股 | +95.0万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #267 | $4,811.4万 | 91.8万股 | $4,281.6万 | 121.1万股 | -29.3万股-24.16% | 减仓 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| 0.03% | 0.01% | #124 | $4,803.1万 | 91.7万股 | $1,092.4万 | 30.9万股 | +60.8万股+196.74% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #103 | $4,397.6万 | 83.8万股 | $3,016.7万 | 94.2万股 | -10.4万股-11.05% | 减仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.07% | 0.06% | #83 | $4,354.1万 | 83.1万股 | $3,931.1万 | 111.2万股 | -28.1万股-25.25% | 减仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.12% | 0.12% | #64 | $4,011.1万 | 76.6万股 | $3,298.9万 | 93.3万股 | -16.7万股-17.94% | 减仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.8% | 0.64% | #28 | $3,671.0万 | 70.1万股 | $2,477.5万 | 70.1万股 | 00.00% | 持仓不变 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.09% | 0.07% | #71 | $3,549.3万 | 67.7万股 | $2,395.3万 | 67.7万股 | 00.00% | 持仓不变 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.32% | — | #43 | $3,455.8万 | 66.0万股 | $0 | 0股 | +66.0万股 | 新买入 |
