| 5AM Venture Management, LLC |
| 2.33% | 1.65% | #1 | $671.2万 | 968.2万股 | $595.0万 | 968.2万股 | 00.00% | 持仓不变 |
| Versant Venture Management, LLC |
| 0.86% | 0.87% | #2 | $139.2万 | 200.8万股 | $123.4万 | 200.8万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.01% | 0.01% | #5 | $109.2万 | 157.5万股 | $96.8万 | 157.5万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #12 | $52.9万 | 76.4万股 | $47.0万 | 76.4万股 | -575股-0.08% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.06% | 0.07% | #3 | $47.1万 | 67.9万股 | $41.7万 | 67.9万股 | 00.00% | 持仓不变 |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.04% | 0.04% | #4 | $16.2万 | 23.3万股 | $14.3万 | 23.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #19 | $16.1万 | 23.3万股 | $17.6万 | 28.6万股 | -5.3万股-18.61% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #14 | $15.1万 | 21.8万股 | $17.0万 | 27.7万股 | -5.9万股-21.35% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #8 | $13.8万 | 19.9万股 | $15.9万 | 25.8万股 | -6.0万股-23.11% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #13 | $8.6万 | 12.4万股 | $6.1万 | 9.9万股 | +2.5万股+25.38% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #10 | $7.2万 | 10.4万股 | $6.4万 | 10.4万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #21 | $5.1万 | 7.4万股 | $4.6万 | 7.5万股 | -1,496股-1.99% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #15 | $5.1万 | 7.4万股 | $2.8万 | 4.6万股 | +2.8万股+61.27% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #16 | $3.9万 | 5.6万股 | $1.2万 | 2.0万股 | +3.6万股+179.65% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #9 | $3.0万 | 4.3万股 | $0 | 0股 | +4.3万股 | 新买入 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #11 | $1.9万 | 2.7万股 | $1,413 | 2,300股 | +2.5万股+1,072.87% | 加仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #6 | $1.5万 | 2.1万股 | $2.5万 | 4.1万股 | -2.0万股-48.70% | 减仓 |
| 工程师之门Engineers Gate Manager LP |
| <0.01% | <0.01% | #7 | $1.4万 | 2.0万股 | $1.2万 | 2.0万股 | 00.00% | 持仓不变 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #17 | $3,182 | 4,589股 | $4,428 | 7,205股 | -2,616股-36.31% | 减仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #22 | $3,158 | 4,557股 | $2,803 | 4,557股 | 00.00% | 持仓不变 |
| 美世全球顾问MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #18 | $2,125 | 3,065股 | $0 | 0股 | +3,065股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #33 | $1,711 | 2,469股 | $1.9万 | 4,952股 | -2,483股-50.14% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #34 | $455 | 655股 | $1.1万 | 1.8万股 | -1.7万股-96.38% | 减仓 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #25 | $413 | 600股 | $364 | 600股 | 00.00% | 持仓不变 |
| 加拿大国家银行NATIONAL BANK OF CANADA /FI/ |
| <0.01% | <0.01% | #27 | $275 | 400股 | $242 | 400股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #41 | $44 | 66股 | $39 | 66股 | 00.00% | 持仓不变 |
| 苏黎世州银行Zurcher Kantonalbank (Zurich Cantonalbank) |
| <0.01% | <0.01% | #35 | $36 | 52股 | $32 | 52股 | 00.00% | 持仓不变 |
| 道明加拿大TD Waterhouse Canada Inc. |
| <0.01% | <0.01% | #31 | $35 | 52股 | $51 | 79股 | -27股-34.18% | 减仓 |
| 魁北克Desjardins联合会Federation des caisses Desjardins du Quebec |
| <0.01% | <0.01% | #30 | $35 | 51股 | $31 | 51股 | 00.00% | 持仓不变 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #36 | $27 | 39股 | $24 | 39股 | 00.00% | 持仓不变 |
| Optiver控股Optiver Holding B.V. |
| <0.01% | <0.01% | #40 | $14 | 20股 | $12 | 20股 | 00.00% | 持仓不变 |
| CoreCap 顾问CoreCap Advisors, LLC |
| <0.01% | <0.01% | #28 | $6 | 8股 | $5 | 8股 | 00.00% | 持仓不变 |
| 琼斯金融JONES FINANCIAL COMPANIES LLLP |
| <0.01% | — | #41 | $5 | 8股 | $0 | 0股 | +8股 | 新买入 |
| GILPIN WEALTH MANAGEMENT, LLC |
| <0.01% | — | #20 | $3 | 4股 | $0 | 0股 | +4股 | 新买入 |
| Integrated Wealth ConceptsIntegrated Wealth Concepts LLC |
| <0.01% | — | #39 | $2 | 2股 | $0 | 0股 | +2股 | 新买入 |
| Plante Moran Financial Advisors, LLC |
| <0.01% | <0.01% | #31 | $2 | 3股 | $2 | 3股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | — | #43 | $1 | 1股 | $0 | 0股 | +1股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #43 | $1 | 1股 | $0 | 0股 | +1股 | 新买入 |
| 港湾投资HARBOUR INVESTMENTS, INC. |
| <0.01% | <0.01% | #38 | $1 | 1股 | $1 | 1股 | 00.00% | 持仓不变 |
| IFP顾问IFP Advisors, Inc |
| <0.01% | <0.01% | #37 | $1 | 1股 | $1 | 2股 | -1股-50.00% | 减仓 |
| NFSG Corp |
| <0.01% | <0.01% | #29 | $1 | 1股 | $1 | 1股 | 00.00% | 持仓不变 |
| Leo H. Evart, Inc. |
| <0.01% | <0.01% | #23 | $1 | 1股 | $1 | 1股 | 00.00% | 持仓不变 |
| PFS Partners, LLC |
| <0.01% | <0.01% | #26 | $1 | 1股 | $1 | 1股 | 00.00% | 持仓不变 |
| MCGUIRE CAPITAL ADVISORS INC |
| <0.01% | <0.01% | #24 | $1 | 2股 | $1 | 2股 | 00.00% | 持仓不变 |
