| Samsara BioCapital, LLC |
| 0.92% | 1.15% | #1 | $1,123.8万 | 29.8万股 | $1,183.8万 | 29.8万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #10 | $1,016.1万 | 27.0万股 | $818.1万 | 20.6万股 | +6.4万股+30.82% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #19 | $980.4万 | 26.0万股 | $1,032.7万 | 26.0万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.12% | 0.18% | #5 | $613.7万 | 16.3万股 | $646.5万 | 16.3万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.03% | 0.03% | #7 | $558.4万 | 14.8万股 | $588.2万 | 14.8万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $355.7万 | 9.4万股 | $432.0万 | 10.9万股 | -1.4万股-13.27% | 减仓 |
| Trails Edge Capital Partners, LP |
| 0.51% | 1.27% | #2 | $320.7万 | 8.5万股 | $553.6万 | 14.0万股 | -5.4万股-38.96% | 减仓 |
| Aisling Capital Management LP |
| 0.4% | — | #3 | $188.3万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #14 | $148.9万 | 4.0万股 | $53.1万 | 1.3万股 | +2.6万股+195.47% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #27 | $122.3万 | 3.2万股 | $130.5万 | 3.3万股 | -416股-1.26% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #15 | $65.7万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #24 | $61.1万 | 1.6万股 | $64.0万 | 1.6万股 | +113股+0.70% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #40 | $55.5万 | 1.5万股 | $50.0万 | 1.3万股 | +2,129股+16.89% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | — | #30 | $51.6万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #37 | $46.2万 | 1.2万股 | $42.3万 | 1.1万股 | +1,600股+15.00% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #22 | $43.2万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| Verdad Advisers, LP |
| 0.32% | — | #4 | $33.9万 | 8,996股 | $0 | 0股 | +8,996股 | 新买入 |
| Integrated Quantitative Investments LLC |
| 0.05% | — | #6 | $30.9万 | 8,210股 | $0 | 0股 | +8,210股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #34 | $30.2万 | 8,023股 | $0 | 0股 | +8,023股 | 新买入 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #11 | $23.7万 | 6,305股 | $0 | 0股 | +6,305股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| <0.01% | — | #13 | $23.5万 | 6,240股 | $0 | 0股 | +6,240股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #32 | $23.1万 | 6,123股 | $71.6万 | 1.8万股 | -1.2万股-66.08% | 减仓 |
| Pathstone控股Pathstone Holdings, LLC |
| <0.01% | <0.01% | #17 | $22.9万 | 6,073股 | $24.1万 | 6,073股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #23 | $22.4万 | 5,947股 | $0 | 0股 | +5,947股 | 新买入 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #20 | $22.3万 | 5,923股 | $0 | 0股 | +5,923股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #33 | $22.2万 | 5,906股 | $0 | 0股 | +5,906股 | 新买入 |
| China Universal Asset Management Co., Ltd. |
| 0.01% | — | #8 | $9.4万 | 2,500股 | $0 | 0股 | +2,500股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #38 | $8.2万 | 2,175股 | $22.4万 | 5,636股 | -3,461股-61.41% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #31 | $6.8万 | 1,802股 | $357 | 9股 | +1,793股+19,922.22% | 加仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #35 | $4.8万 | 1,275股 | $5.1万 | 1,275股 | 00.00% | 持仓不变 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #29 | $3.8万 | 1,020股 | $4.4万 | 1,119股 | -99股-8.85% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #43 | $3.8万 | 1,009股 | $1.7万 | 746股 | +263股+35.25% | 加仓 |
| VALLEY NATIONAL ADVISERS INC |
| <0.01% | — | #9 | $3.7万 | 980股 | $0 | 0股 | +980股 | 新买入 |
| Farther金融顾问Farther Finance Advisors, LLC |
| <0.01% | <0.01% | #25 | $1.1万 | 283股 | $1.1万 | 283股 | 00.00% | 持仓不变 |
| Strengthening Families & Communities, LLC |
| <0.01% | <0.01% | #12 | $6,513 | 173股 | $6,861 | 173股 | 00.00% | 持仓不变 |
| State of Wyoming |
| <0.01% | — | #18 | $5,535 | 147股 | $0 | 0股 | +147股 | 新买入 |
| Truvestments Capital LLC |
| <0.01% | — | #16 | $5,384 | 143股 | $0 | 0股 | +143股 | 新买入 |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #41 | $4,217 | 112股 | $4,000 | 112股 | 00.00% | 持仓不变 |
| Activest Wealth Management |
| <0.01% | <0.01% | #21 | $1,883 | 50股 | $1,983 | 50股 | 00.00% | 持仓不变 |
| CoreCap 顾问CoreCap Advisors, LLC |
| <0.01% | <0.01% | #28 | $1,694 | 45股 | $1,785 | 45股 | 00.00% | 持仓不变 |
| 平行顾问Parallel Advisors, LLC |
| <0.01% | <0.01% | #36 | $1,431 | 38股 | $1,507 | 38股 | 00.00% | 持仓不变 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #44 | $75 | 2股 | $79 | 2股 | 00.00% | 持仓不变 |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #39 | $75 | 2股 | $0 | 0股 | +2股 | 新买入 |
| Strategic Wealth Partners, Ltd. |
| <0.01% | <0.01% | #42 | $38 | 1股 | $40 | 1股 | 00.00% | 持仓不变 |
