| 富达投资FMR LLC |
| 0.07% | 0.06% | #80 | $16.42亿 | 441.8万股 | $11.30亿 | 437.4万股 | +4.4万股+1.01% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.02% | 0.02% | #133 | $15.54亿 | 418.1万股 | $10.18亿 | 394.0万股 | +24.1万股+6.12% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 9.64% | 7.34% | #4 | $10.74亿 | 288.9万股 | $7.46亿 | 288.9万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.02% | #123 | $5.85亿 | 157.5万股 | $3.76亿 | 145.7万股 | +11.8万股+8.11% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #154 | $5.02亿 | 135.1万股 | $3.40亿 | 131.4万股 | +3.7万股+2.79% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #186 | $4.61亿 | 124.1万股 | $3.01亿 | 116.5万股 | +7.5万股+6.46% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 12.03% | 12.06% | #2 | $3.49亿 | 93.9万股 | $2.98亿 | 115.3万股 | -21.4万股-18.54% | 减仓 |
| 资本世界投资者Capital World Investors |
| 0.03% | 0.03% | #113 | $2.89亿 | 77.8万股 | $2.13亿 | 82.5万股 | -4.7万股-5.68% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #159 | $2.60亿 | 69.9万股 | $1.66亿 | 64.4万股 | +5.5万股+8.54% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.01% | #126 | $2.55亿 | 68.7万股 | $1.25亿 | 48.5万股 | +20.2万股+41.71% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 1.79% | 1.61% | #13 | $2.47亿 | 66.3万股 | $1.60亿 | 62.0万股 | +4.4万股+7.07% | 加仓 |
| Redmile Group, LLC |
| 15.77% | 11.52% | #1 | $2.35亿 | 63.2万股 | $1.74亿 | 67.4万股 | -4.2万股-6.16% | 减仓 |
| 威廉·布莱尔投资管理WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.64% | 0.35% | #24 | $2.12亿 | 57.0万股 | $1.05亿 | 40.7万股 | +16.3万股+40.03% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 3.9% | 3.2% | #9 | $1.79亿 | 48.1万股 | $1.24亿 | 48.1万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.03% | #115 | $1.77亿 | 47.6万股 | $1.21亿 | 46.9万股 | +7,048股+1.50% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.07% | 0.06% | #81 | $1.21亿 | 32.5万股 | $9,054.7万 | 35.1万股 | -2.6万股-7.31% | 减仓 |
| 景顺Invesco Ltd. |
| 0.01% | 0.01% | #194 | $1.21亿 | 32.5万股 | $6,493.5万 | 25.1万股 | +7.3万股+29.19% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #190 | $1.11亿 | 29.9万股 | $5,552.6万 | 21.5万股 | +8.4万股+39.03% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #171 | $1.05亿 | 28.4万股 | $6,521.6万 | 25.2万股 | +3.1万股+12.41% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.02% | 0.01% | #137 | $9,734.7万 | 26.2万股 | $4,630.8万 | 17.9万股 | +8.3万股+46.11% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | 0.01% | #193 | $9,627.4万 | 25.9万股 | $4,926.0万 | 27.3万股 | -1.4万股-5.19% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #105 | $9,538.7万 | 25.7万股 | $0 | 0股 | +25.7万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #227 | $9,530.8万 | 25.6万股 | $6,733.0万 | 26.1万股 | -4,216股-1.62% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #170 | $9,471.2万 | 25.5万股 | $6,251.0万 | 24.2万股 | +1.3万股+5.31% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #249 | $8,752.5万 | 23.5万股 | $4,141.0万 | 23.5万股 | +913股+0.39% | 加仓 |
| VESTOR CAPITAL, LLC |
| 4.91% | <0.01% | #8 | $7,818.8万 | 70.1万股 | $5.2万 | 200股 | +70.1万股+350,357.00% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.01% | #151 | $7,044.2万 | 19.0万股 | $4,628.1万 | 17.9万股 | +1.0万股+5.79% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.03% | 0.02% | #117 | $6,301.7万 | 17.0万股 | $4,186.6万 | 16.2万股 | +7,480股+4.62% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | 0.01% | #185 | $6,080.9万 | 16.4万股 | $3,856.9万 | 14.9万股 | +1.4万股+9.58% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #210 | $6,021.6万 | 16.2万股 | $4,123.4万 | 16.0万股 | +2,391股+1.50% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| 0.02% | 0.01% | #147 | $5,897.4万 | 15.9万股 | $3,953.5万 | 15.6万股 | +2,611股+1.67% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.17% | 0.15% | #53 | $5,597.9万 | 15.1万股 | $3,890.7万 | 15.1万股 | 00.00% | 持仓不变 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #166 | $5,445.7万 | 14.7万股 | $3,703.5万 | 14.3万股 | +3,152股+2.20% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.23% | 0.29% | #46 | $4,854.0万 | 13.1万股 | $4,908.1万 | 19.0万股 | -5.9万股-31.26% | 减仓 |
| BRAIDWELL LP |
| 1.77% | 1.57% | #14 | $4,793.6万 | 12.9万股 | $4,712.4万 | 18.2万股 | -5.3万股-29.30% | 减仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.04% | 0.03% | #104 | $4,625.1万 | 12.4万股 | $2,800.1万 | 10.8万股 | +1.6万股+14.80% | 加仓 |
| 时代广场资本管理TimesSquare Capital Management, LLC |
| 0.61% | 0.49% | #27 | $4,145.8万 | 11.2万股 | $2,902.0万 | 11.2万股 | -797股-0.71% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #271 | $4,080.9万 | 11.0万股 | $4,258.2万 | 16.5万股 | -5.5万股-33.39% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #108 | $4,006.5万 | 10.8万股 | $2,858.7万 | 11.1万股 | -2,867股-2.59% | 减仓 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.1% | 0.07% | #71 | $3,921.7万 | 10.6万股 | $2,383.9万 | 9.2万股 | +1.3万股+14.33% | 加仓 |
| 1832资产管理1832 Asset Management L.P. |
| 0.02% | 0.01% | #139 | $3,690.7万 | 9.9万股 | $1,100.4万 | 4.3万股 | +5.7万股+133.10% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.12% | — | #62 | $3,668.6万 | 9.9万股 | $0 | 0股 | +9.9万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #145 | $3,428.1万 | 9.2万股 | $2,403.2万 | 9.3万股 | -797股-0.86% | 减仓 |
| Handelsbanken Fonder AB |
| 0.1% | 0.08% | #72 | $3,360.2万 | 9.0万股 | $2,361.0万 | 9.1万股 | -993股-1.09% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #303 | $3,348.0万 | 8.7万股 | $2,447.3万 | 9.9万股 | -1.2万股-11.87% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.05% | — | #18 | $3,159.2万 | 8.5万股 | $0 | 0股 | +8.5万股 | 新买入 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.58% | 0.35% | #30 | $3,092.3万 | 8.3万股 | $1,785.0万 | 6.9万股 | +1.4万股+20.41% | 加仓 |
| S SQUARED TECHNOLOGY, LLC |
| 8.94% | 8.43% | #5 | $2,882.1万 | 7.8万股 | $2,227.1万 | 8.6万股 | -8,670股-10.06% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 0.61% | 2.96% | #29 | $2,881.6万 | 7.8万股 | $1.24亿 | 48.2万股 | -40.4万股-83.91% | 减仓 |
| Biondo Investment Advisors, LLC |
| 3.23% | 2.39% | #10 | $2,636.8万 | 7.1万股 | $1,861.1万 | 7.2万股 | -1,100股-1.53% | 减仓 |
