| BlackRock, Inc. |
| 0.07% | 0.06% | #352 | $4.67B | 8.3M | $3.39B | 8.0M | +345,365+4.32% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.06% | 0.05% | #401 | $2.88B | 5.1M | $2.14B | 5.0M | +87,074+1.73% | Add |
| STATE STREET CORP |
| 0.06% | 0.05% | #383 | $2.18B | 3.9M | $1.56B | 3.7M | +203,608+5.53% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.09% | 0.08% | #295 | $2.07B | 3.7M | $1.53B | 3.6M | +80,141+2.22% | Add |
| Invesco Ltd. |
| 0.14% | 0.08% | #224 | $1.81B | 3.2M | $524.2M | 1.2M | +2.0M+161.59% | Add |
| BAILLIE GIFFORD & CO |
| 1.56% | 1.02% | #39 | $1.72B | 3.1M | $1.04B | 2.5M | +599,760+24.38% | Add |
| FMR LLC |
| 0.07% | 0.05% | #337 | $1.70B | 3.0M | $1.02B | 2.4M | +628,618+26.23% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.07% | 0.06% | #355 | $1.29B | 2.3M | $954.9M | 2.3M | +56,479+2.50% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.2% | 0.19% | #181 | $1.18B | 2.1M | $1.03B | 2.4M | -314,974-13.03% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.1% | 0.04% | #277 | $1.05B | 1.9M | $334.9M | 788,636 | +1.1M+137.35% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 2.73% | 1.9% | #27 | $836.1M | 1.5M | $451.9M | 1.1M | +427,356+40.16% | Add |
| SANDS CAPITAL MANAGEMENT, LLC |
| 3.08% | 2.61% | #22 | $830.2M | 1.5M | $664.4M | 1.6M | -83,687-5.35% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.06% | 0.05% | #424 | $732.4M | 1.3M | $469.2M | 1.1M | +201,793+18.27% | Add |
| EDGEWOOD MANAGEMENT LLC |
| 6.5% | 5.56% | #8 | $630.5M | 1.1M | $861.5M | 2.0M | -903,748-44.55% | Reduce |
| MORGAN STANLEY |
| 0.03% | 0.04% | #580 | $610.6M | 1.1M | $720.6M | 1.0M | +84,978+8.46% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.19% | 0.15% | #189 | $574.1M | 1.0M | $433.3M | 1.0M | +4,731+0.47% | Add |
| UBS Group AG |
| 0.07% | 0.06% | #358 | $536.9M | 957,791 | $395.2M | 930,657 | +27,134+2.92% | Add |
| NORGES BANK |
| 0.05% | 0.05% | #451 | $522.4M | 931,827 | $387.5M | 736,824 | +195,003+26.47% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.04% | 0.02% | #520 | $466.6M | 832,244 | $211.3M | 497,657 | +334,587+67.23% | Add |
| CITADEL ADVISORS LLC |
| 0.05% | 0.04% | #457 | $445.6M | 794,859 | $258.3M | 608,142 | +186,717+30.70% | Add |
| NORTHERN TRUST CORP |
| 0.05% | 0.04% | #458 | $434.1M | 774,281 | $324.8M | 764,804 | +9,477+1.24% | Add |
| Bank of New York Mellon Corp |
| 0.07% | 0.06% | #364 | $409.7M | 730,899 | $301.0M | 708,831 | +22,068+3.11% | Add |
| FRANKLIN RESOURCES INC |
| 0.08% | 0.1% | #316 | $393.4M | 701,731 | $444.9M | 1.0M | -345,742-33.01% | Reduce |
| BROADWOOD CAPITAL INC |
| 20.32% | 20.76% | #1 | $388.8M | 693,504 | $294.5M | 693,504 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.05% | 0.04% | #469 | $362.9M | 647,298 | $248.8M | 585,748 | +61,550+10.51% | Add |
| JANE STREET GROUP, LLC |
| 0.03% | 0.02% | #595 | $362.4M | 646,382 | $138.5M | 326,109 | +320,273+98.21% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.06% | 0.06% | #385 | $353.9M | 631,247 | $269.1M | 633,617 | -2,370-0.37% | Reduce |
| Nuveen, LLC |
| 0.08% | 0.06% | #323 | $329.0M | 586,940 | $238.4M | 561,268 | +25,672+4.57% | Add |
| JPMORGAN CHASE & CO |
| 0.02% | 0.02% | #742 | $299.6M | 586,714 | $265.5M | 639,542 | -52,828-8.26% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.02% | 0.02% | #715 | $286.7M | 511,379 | $279.9M | 659,109 | -147,730-22.41% | Reduce |
| Winslow Capital Management, LLC |
| 0.97% | — | #60 | $283.0M | 504,819 | $0 | 0 | +504,819 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| 0.06% | 0.05% | #427 | $257.5M | 459,263 | $192.1M | 452,430 | +6,833+1.51% | Add |
| Clearbridge Investments, LLC |
| 0.21% | 0.14% | #179 | $249.5M | 445,112 | $158.1M | 372,326 | +72,786+19.55% | Add |
| Legal & General Group Plc |
| 0.05% | 0.04% | #456 | $244.7M | 436,433 | $180.7M | 425,516 | +10,917+2.57% | Add |
| Amundi |
| 0.06% | 0.05% | #413 | $243.6M | 434,440 | $185.3M | 436,435 | -1,995-0.46% | Reduce |
| SHEPHERD WEALTH MANAGEMENT Ltd LIABILITY Co |
| 0.13% | — | #237 | $234.2M | 380 | $0 | 0 | +380 | New Buy |
| DEUTSCHE BANK AG\ |
| 0.07% | 0.05% | #371 | $228.4M | 407,432 | $156.6M | 368,651 | +38,781+10.52% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.04% | 0.03% | #492 | $220.5M | 393,304 | $132.4M | 311,847 | +81,457+26.12% | Add |
| Strategy Capital LLC |
| 13.36% | 13.82% | #3 | $216.7M | 386,596 | $169.0M | 397,898 | -11,302-2.84% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| 0.06% | 0.05% | #418 | $214.1M | 381,944 | $168.2M | 401,154 | -19,210-4.79% | Reduce |
| Walleye Trading LLC |
| 0.23% | 0.19% | #166 | $202.2M | 360,745 | $114.8M | 270,388 | +90,357+33.42% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.1% | 0.05% | #291 | $199.9M | 354,265 | $102.7M | 239,774 | +114,491+47.75% | Add |
| PEAK6 LLC |
| 0.37% | 0.26% | #121 | $178.9M | 319,202 | $112.5M | 264,953 | +54,249+20.47% | Add |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC |
| 3.87% | 3.52% | #15 | $169.4M | 302,151 | $122.4M | 288,211 | +13,940+4.84% | Add |
| IMC-Chicago, LLC |
| 0.04% | <0.01% | #527 | $164.9M | 294,100 | $3.9M | 9,224 | +284,876+3,088.42% | Add |
| Artemis Investment Management LLP |
| 1.35% | 0.29% | #47 | $151.2M | 269,751 | $27.3M | 64,360 | +205,391+319.13% | Add |
| SEI INVESTMENTS CO |
| 0.13% | 0.04% | #239 | $149.9M | 267,434 | $48.8M | 114,856 | +152,578+132.84% | Add |
| ROYAL BANK OF CANADA |
| 0.02% | 0.02% | #682 | $140.7M | 250,963 | $107.3M | 252,717 | -1,754-0.69% | Reduce |
| HSBC HOLDINGS PLC |
| 0.06% | 0.05% | #431 | $134.4M | 240,928 | $91.9M | 216,795 | +24,133+11.13% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.11% | 0.13% | #271 | $122.4M | 218,364 | $129.3M | 305,134 | -86,770-28.44% | Reduce |
