13FBOX
Siren, L.L.C. · 13F Holdings
Options Calculator Rankings

Siren, L.L.C.

No.970 Data as of 2026Q2
Latest AUM (Q2 2026)
$4.94B
QoQ Change Q1 2026
+$1.33B+37.0%
Holdings
116
New Buys
26
Adds
32
Reduces
20
Exits
10
Unchanged
38
Holdings Value Trend
Holdings by Sector
Stock Ownership TrendPortfolio %Prev Q %Q2 2026 ValueQ2 2026 SharesPrev Q ValuePrev Q SharesShares ChangeAction
SCHOLAR ROCK HLDG CORPSRRK
10.66%14.75%$526.6M9.6M$532.2M10.8M-1.3M-11.55%Reduce
KYMERA THERAPEUTICS INCKYMR
6.81%7.36%$336.7M2.9M$265.4M3.2M-251,000-7.88%Reduce
EERASCA INCERAS
4.23%5.04%$208.8M11.4M$181.9M11.2M+153,535+1.37%Add
VVERADERMICS INCMANE
4.12%2.64%$203.5M1.7M$95.1M1.5M+150,000+9.96%Add
TTANGO THERAPEUTICS INCTNGX
3.91%3.28%$193.2M6.2M$118.3M5.7M+522,259+9.23%Add
RREVOLUTION MEDICINES INC COMRVMD
3.41%3%$168.6M900,000$108.0M1.1M-210,980-18.99%Reduce
BBICARA THERAPEUTICS INCBCAX
3.37%3.2%$166.4M5.6M$115.4M5.8M-200,000-3.45%Reduce
ARROWHEAD PHARMACEUTICALS INARWR
2.83%2.81%$139.8M1.7M$101.3M1.6M+100,000+6.19%Add
BBEONE MEDICINES LTDONC
2.68%3.83%$132.5M465,000$138.1M465,00000.00%Unchanged
EDGEWISE THERAPEUTICS INCEWTX
2.62%3.87%$129.4M3.2M$139.6M4.4M-1.2M-28.12%Reduce
RHYTHM PHARMACEUTICALS INCRYTM
2.55%1.75%$126.2M1.1M$63.1M725,511+410,764+56.62%Add
LLEXICON PHARMACEUTICALS INC COM NEWLXRX
2.15%1.92%$106.3M44.3M$69.1M44.3M00.00%Unchanged
EENLIVEN THERAPEUTICS INCELVN
1.82%0.81%$90.1M1.8M$29.3M746,226+1.0M+137.78%Add
SSPYRE THERAPEUTICS INCSYRE
1.74%1.14%$86.0M968,598$41.3M818,598+150,000+18.32%Add
PPARABILIS MEDICINES INCPBLS
1.66%$81.9M3.0M$00+3.0MNew Buy
XENON PHARMACEUTICALS INCXENE
1.61%2.13%$79.6M1.3M$76.7M1.3M00.00%Unchanged
SOLID BIOSCIENCES INCSLDB
1.55%1.53%$76.8M7.7M$55.4M7.7M00.00%Unchanged
ABIVAX SAABVX
1.55%$76.8M576,000$00+576,000New Buy
HHEMAB THERAPEUTICS HLDGS INCCOAG
1.55%$76.6M2.1M$00+2.1MNew Buy
ARCUS BIOSCIENCES INCRCUS
1.51%1.8%$74.6M2.4M$65.0M3.0M-586,647-19.51%Reduce
COGENT BIOSCIENCES INCCOGT
1.46%1.82%$72.0M1.9M$65.8M1.7M+150,000+8.78%Add
RELAY THERAPEUTICS INCRLAY
1.38%$68.3M3.7M$00+3.7MNew Buy
TAYSHA GENE THERAPIES INCTSHA
1.36%1.09%$67.1M9.8M$39.5M8.8M+1.0M+11.51%Add
DDEFINIUM THERAPEUTICS INCDFTX
1.35%0.48%$66.8M1.4M$17.4M919,493+500,000+54.38%Add
STOKE THERAPEUTICS INCSTOK
1.32%1.8%$65.3M2.0M$65.0M2.0M00.00%Unchanged
DISC MEDICINE INCIRON
1.31%1.75%$65.0M888,401$63.2M988,401-100,000-10.12%Reduce
CYTOKINETICS INCCYTK
1.31%1.12%$64.7M758,952$40.5M613,952+145,000+23.62%Add
SSEPTERNA INCSEPN
1.29%1.33%$63.6M1.9M$48.1M2.0M-100,000-5.00%Reduce
OOLEMA PHARMACEUTICALS INC COMOLMA
1.23%1.97%$60.8M4.9M$70.9M4.8M+100,000+2.10%Add
CCRINETICS PHARMACEUTICALS INCRNX
1.08%1.92%$53.2M1.4M$69.1M1.9M-482,848-25.36%Reduce
KKAILERA THERAPEUTICS INCKLRA
0.99%$48.8M2.2M$00+2.2MNew Buy
DDYNE THERAPEUTICS INCDYN
0.96%1.12%$47.3M2.1M$40.4M2.2M-100,000-4.49%Reduce
STRUCTURE THERAPEUTICS INCGPCR
0.95%1.78%$46.9M872,967$64.0M1.3M-455,731-34.30%Reduce
TTABOOLA.COM LTDTBLA
0.85%0.86%$42.1M8.4M$30.9M10.0M-1.5M-15.51%Reduce
PALVELLA THERAPEUTICS INC NEPVLA
0.8%0.89%$39.3M257,485$32.1M257,48500.00%Unchanged
SSILENCE THERAPEUTICS PLCSLN
0.74%0.43%$36.4M3.3M$15.3M2.9M+400,000+13.74%Add
DENALI THERAPEUTICS INCDNLI
0.73%0.74%$35.9M1.4M$26.8M1.4M00.00%Unchanged
RREMITLY GLOBAL INCRELY
0.7%0.67%$34.6M1.5M$24.2M1.5M00.00%Unchanged
CCULLINAN THERAPEUTICS INCCGEM
0.7%0.47%$34.5M1.9M$17.0M1.2M+700,000+58.66%Add
CAPITAL ONE FINL CORPCOF
0.7%$34.4M171,615$00+171,615New Buy
TREVI THERAPEUTICS INCTRVI
0.67%0.59%$33.3M1.8M$21.3M1.8M00.00%Unchanged
OORIC PHARMACEUTICALS INCORIC
0.66%1.05%$32.5M3.0M$38.0M3.0M00.00%Unchanged
ALPHABET INCGOOGL
0.65%0.52%$32.2M90,000$18.9M65,703+24,297+36.98%Add
DBV TECHNOLOGIES S ADBVT
0.62%1.08%$30.5M1.9M$38.8M1.9M00.00%Unchanged
AABSCI CORPORATION COMABSI
0.58%0.15%$28.7M2.5M$5.4M1.8M+674,764+37.49%Add
SSIONNA THERAPEUTICS INCSION
0.54%0.33%$26.9M610,515$12.0M300,000+310,515+103.51%Add
RRAPPORT THERAPEUTICS INCRAPP
0.54%0.56%$26.7M641,469$20.1M641,46900.00%Unchanged
AAMYLYX PHARMACEUTICALS INCAMLX
0.54%0.47%$26.6M1.5M$17.1M1.2M+250,586+20.37%Add
ANNEXON INCANNX
0.52%0.61%$25.5M4.5M$21.9M4.0M+500,000+12.63%Add
MMONOPAR THERAPEUTICS INCMNPR
0.51%0.41%$25.0M270,118$14.8M270,11800.00%Unchanged

🧭 Institutional Sector Flow Heatmap

Net Outflow Net Inflow