| OORCHARD THERAPEUTICS PLC |
| 29.25% | 3.72% | $98.5M | 12.3M | $12.6M | 2.5M | +9.8M+389.07% | Add |
| PPLIANT THERAPEUTICS INCPLRX |
| 15.53% | 16.75% | $52.3M | 3.2M | $56.6M | 3.2M | -95,618-2.94% | Reduce |
| RREPARE THERAPEUTICS INC |
| 10.69% | 9.38% | $36.0M | 3.0M | $31.7M | 3.0M | +17,940+0.60% | Add |
| CCULLINAN THERAPEUTICS INCCGEM |
| 9.17% | 10.86% | $30.9M | 3.4M | $36.7M | 3.4M | 00.00% | Unchanged |
| AACELYRIN Inc |
| 6.83% | 16.46% | $23.0M | 2.3M | $55.7M | 2.7M | -400,816-15.05% | Reduce |
| LLARIMAR THERAPEUTICS INC COMLRMR |
| 4% | 2.58% | $13.5M | 3.4M | $8.7M | 3.4M | 00.00% | Unchanged |
 KEROS THERAPEUTICS INC COMKROS |
| 3.86% | 4.78% | $13.0M | 407,633 | $16.2M | 402,118 | +5,515+1.37% | Add |
| IIKENA ONCOLOGY INC |
| 2.8% | 4.12% | $9.4M | 2.2M | $13.9M | 2.1M | +58,894+2.78% | Add |
| UULTRAGENYX PHARMACEUTICAL INRARE |
| 2.28% | 1.16% | $7.7M | 215,000 | $3.9M | 85,000 | +130,000+152.94% | Add |
| CCOMPASS THERAPEUTICS INCCMPX |
| 1.66% | 2.66% | $5.6M | 2.8M | $9.0M | 2.8M | 00.00% | Unchanged |
 MINERALYS THERAPEUTICS INCMLYS |
| 1.6% | — | $5.4M | 568,379 | $0 | 0 | +568,379 | New Buy |
| IInozyme Pharma Inc |
| 1.58% | 1.97% | $5.3M | 1.3M | $6.7M | 1.2M | +75,000+6.28% | Add |
| SSYROS PHARMACEUTICALS INC |
| 1.52% | 0.71% | $5.1M | 1.3M | $2.4M | 767,445 | +531,914+69.31% | Add |
| BBLUEPRINT MEDICINES CORP COM2655787D |
| 1.39% | — | $4.7M | 92,888 | $0 | 0 | +92,888 | New Buy |
| DDIREXION SHS ETF TRJDSTGBP |
| 1.38% | 1.38% | $4.6M | 225,000 | $4.7M | 325,000 | -100,000-30.77% | Reduce |
| 22SEVENTY BIO INC |
| 1.17% | 2.55% | $3.9M | 1.0M | $8.6M | 852,007 | +150,000+17.61% | Add |
| MMOONLAKE IMMUNOTHERAPEUTICSMLTX |
| 1.02% | — | $3.4M | 60,000 | $0 | 0 | +60,000 | New Buy |
| OOVID THERAPEUTICS INCOVID |
| 0.99% | 0.84% | $3.3M | 864,822 | $2.8M | 864,822 | 00.00% | Unchanged |
| SSAGIMET BIOSCIENCES INCSGMT |
| 0.91% | — | $3.1M | 348,842 | $0 | 0 | +348,842 | New Buy |
| OOMEGA THERAPEUTICS INC |
| 0.67% | 1.75% | $2.3M | 1.1M | $5.9M | 1.1M | 00.00% | Unchanged |
| BBLACK DIAMOND THERAPEUTICS INC COMBDTX |
| 0.61% | 1.12% | $2.1M | 720,000 | $3.8M | 750,000 | -30,000-4.00% | Reduce |
| RRALLYBIO CORP |
| 0.39% | 0.91% | $1.3M | 390,734 | $3.1M | 542,774 | -152,040-28.01% | Reduce |
 DISC MEDICINE INCIRON |
| 0.35% | 1.64% | $1.2M | 25,000 | $5.6M | 125,139 | -100,139-80.02% | Reduce |
| GGRAPHITE BIO INC. |
| 0.17% | 0.18% | $572,726 | 230,938 | $600,439 | 230,938 | 00.00% | Unchanged |
| FFREELINE THERAPEUTICS F UNSPONSORED ADR 1 ADR REPS 15 ORD SHS |
| 0.11% | 0.02% | $372,613 | 86,654 | $55,898 | 25,999 | +60,655+233.30% | Add |
| PPRECISION BIOSCIENCES INCORPORATED COM NEWDTIL |
| 0.06% | 0.25% | $207,043 | 606,629 | $843,471 | 1.6M | -996,928-62.17% | Reduce |
