 PTC THERAPEUTICS INCPTCT |
| 10.95% | 9.6% | $75.0M | 918,846 | $62.8M | 921,607 | -2,761-0.30% | Reduce |
 ACADIA HEALTHCARE COMPANY INACHC |
| 10.59% | — | $72.5M | 2.9M | $0 | 0 | +2.9M | New Buy |
 INSMED INCINSM |
| 6.45% | 10.39% | $44.1M | 413,980 | $67.9M | 415,269 | -1,289-0.31% | Reduce |
| AANAPTYSBIO INCANAB |
| 5.95% | 5.41% | $40.7M | 603,489 | $35.4M | 638,161 | -34,672-5.43% | Reduce |
 BIOMARIN PHARMACEUTICAL INCBMRN |
| 5.71% | 5.92% | $39.1M | 682,777 | $38.7M | 685,182 | -2,405-0.35% | Reduce |
| DDYNE THERAPEUTICS INCDYN |
| 5.35% | 4.58% | $36.6M | 1.6M | $30.0M | 1.7M | -5,451-0.33% | Reduce |
 UNITED THERAPEUTICS CORP DELUTHR |
| 4.96% | 5.7% | $33.9M | 62,587 | $37.2M | 62,809 | -222-0.35% | Reduce |
 DISC MEDICINE INCIRON |
| 4.45% | 3.93% | $30.5M | 416,646 | $25.7M | 401,719 | +14,927+3.72% | Add |
 BIOGEN INCBIIB |
| 4.43% | 3.95% | $30.3M | 140,279 | $25.8M | 140,719 | -440-0.31% | Reduce |
| IIOVANCE BIOTHERAPEUTICS INCIOVA |
| 3.22% | 3.41% | $22.0M | 5.3M | $22.3M | 6.3M | -1.1M-16.59% | Reduce |
| UULTRAGENYX PHARMACEUTICAL INRARE |
| 2.91% | 1.91% | $19.9M | 596,495 | $12.5M | 596,495 | 00.00% | Unchanged |
| NNOVOCURE LTDNVCR |
| 2.83% | 2.13% | $19.4M | 1.3M | $14.0M | 1.3M | 00.00% | Unchanged |
 SYNDAX PHARMACEUTICALS INCSNDX |
| 2.76% | 3.09% | $18.9M | 864,986 | $20.2M | 864,986 | 00.00% | Unchanged |
 ANNEXON INCANNX |
| 2.46% | 2.5% | $16.8M | 2.9M | $16.3M | 2.9M | 00.00% | Unchanged |
| BBICARA THERAPEUTICS INCBCAX |
| 2.39% | 1.67% | $16.3M | 550,408 | $10.9M | 550,408 | 00.00% | Unchanged |
| CCAREDX INCCDNA |
| 2.22% | 1.41% | $15.2M | 531,870 | $9.2M | 531,870 | 00.00% | Unchanged |
| CCELLDEX THERAPEUTICS INC NEWCLDX |
| 2.17% | 1.44% | $14.9M | 399,856 | $9.4M | 296,408 | +103,448+34.90% | Add |
| CCOMPASS THERAPEUTICS INCCMPX |
| 1.87% | 1.23% | $12.8M | 5.8M | $8.0M | 1.5M | +4.3M+285.06% | Add |
 ALKERMES PLCALKS |
| 1.86% | 1.31% | $12.7M | 242,560 | $8.6M | 242,560 | 00.00% | Unchanged |
| FFIRST TRACKS BIOTHERAPEUTICSTRAX |
| 1.77% | — | $12.1M | 603,489 | $0 | 0 | +603,489 | New Buy |
 PROTHENA CORP PLCPRTA |
| 1.64% | 1.8% | $11.2M | 1.1M | $11.7M | 1.2M | -65,413-5.41% | Reduce |
| TTRAVERE THERAPEUTICS INCTVTX |
| 1.39% | 1.05% | $9.5M | 167,525 | $6.8M | 230,453 | -62,928-27.31% | Reduce |
 TAYSHA GENE THERAPIES INCTSHA |
| 1.38% | 0.95% | $9.5M | 1.4M | $6.2M | 1.4M | 00.00% | Unchanged |
| AACLARIS THERAPEUTICS INC COMACRS |
| 1.25% | 0.93% | $8.5M | 1.6M | $6.1M | 1.6M | 00.00% | Unchanged |
 AGIOS PHARMACEUTICALS INCAGIO |
| 1.16% | 1.11% | $7.9M | 213,601 | $7.2M | 213,601 | 00.00% | Unchanged |
| CCAPRICOR THERAPEUTICS INC COM NEWCAPR |
| 0.81% | 1.07% | $5.5M | 229,763 | $7.0M | 229,763 | 00.00% | Unchanged |
 ALIGN TECHNOLOGY INC COM USD0.0001ALGN |
| 0.77% | 1.09% | $5.3M | 31,389 | $7.1M | 41,520 | -10,131-24.40% | Reduce |
| OORUKA THERAPEUTICS INC COMORKA |
| 0.47% | 0.45% | $3.2M | 33,546 | $2.9M | 59,985 | -26,439-44.08% | Reduce |
 XENON PHARMACEUTICALS INCXENE |
| 0.45% | 0.46% | $3.1M | 51,345 | $3.0M | 51,345 | 00.00% | Unchanged |
 NEUROCRINE BIOSCIENCES INCNBIX |
| 0.45% | 0.37% | $3.1M | 18,117 | $2.4M | 18,117 | 00.00% | Unchanged |
 EDWARDS LIFESCIENCES CORPEW |
| 0.44% | 0.41% | $3.0M | 33,640 | $2.7M | 33,640 | 00.00% | Unchanged |
 STOKE THERAPEUTICS INCSTOK |
| 0.4% | 0.42% | $2.8M | 84,631 | $2.8M | 84,631 | 00.00% | Unchanged |
 CYTOKINETICS INCCYTK |
| 0.4% | 0.32% | $2.7M | 32,195 | $2.1M | 32,195 | 00.00% | Unchanged |
| PPYXIS ONCOLOGY INC COMMON STOCKPYXS |
| 0.38% | 0.23% | $2.6M | 864,277 | $1.5M | 1.0M | -146,233-14.47% | Reduce |
| EEHEALTH INC COMEHTH |
| 0.32% | 0.29% | $2.2M | 1.5M | $1.9M | 1.5M | 00.00% | Unchanged |
 CRISPR THERAPEUTICSCRSP |
| 0.32% | 0.29% | $2.2M | 39,605 | $1.9M | 39,605 | 00.00% | Unchanged |
| SSAGIMET BIOSCIENCES INCSGMT |
| 0.28% | — | $1.9M | 250,000 | $0 | 0 | +250,000 | New Buy |
| NNUVATION BIO INCNUVB |
| 0.27% | 0.33% | $1.9M | 326,609 | $2.2M | 508,846 | -182,237-35.81% | Reduce |
 BIONTECH SE FUNSPONSORED ADR 1 ADR REPS 1 ORD SHSBNTX |
| 0.27% | 0.27% | $1.8M | 19,614 | $1.7M | 19,614 | 00.00% | Unchanged |
 COMPASS PATHWAYS ADR A FUNSPONSORED ADR 1 ADR REPS 1 ORD SHSCMPS |
| 0.24% | 0.1% | $1.6M | 115,616 | $639,356 | 115,616 | 00.00% | Unchanged |
 HUMANA INC COMHUM |
| 0.23% | 0.11% | $1.6M | 3,985 | $690,959 | 3,985 | 00.00% | Unchanged |
| NNEWAMSTERDAM PHARMA COMPANYNAMS |
| 0.22% | — | $1.5M | 44,359 | $0 | 0 | +44,359 | New Buy |
| MMIRUM PHARMACEUTICALSMIRM |
| 0.2% | — | $1.4M | 348,808 | $0 | 0 | +348,808 | New Buy |
| VVERASTEM INC COM NEWVSTM |
| 0.17% | 0.2% | $1.2M | 309,685 | $1.3M | 246,093 | +63,592+25.84% | Add |
 MADRIGAL PHARMACEUTICALS INCMDGL |
| 0.14% | 0.14% | $959,530 | 1,787 | $935,441 | 1,787 | 00.00% | Unchanged |
| UUROGEN PHARMA LTDURGN |
| 0.13% | 0.07% | $901,600 | 24,500 | $440,510 | 24,500 | 00.00% | Unchanged |
 BICYCLE THERAPEUTICS PLC SPON ADS EACH REP 1 ORD SHSBCYC |
| 0.13% | 0.14% | $856,014 | 201,890 | $936,770 | 201,890 | 00.00% | Unchanged |
 XERIS BIOPHARMA HLDGS INXERS |
| 0.12% | 0.09% | $826,927 | 104,410 | $605,578 | 104,410 | 00.00% | Unchanged |
| AABEONA THERAPEUTICS INC COM NEWABEO |
| 0.1% | 0.07% | $672,786 | 108,865 | $487,715 | 108,865 | 00.00% | Unchanged |
| IINSPIRE MED SYS INCINSP |
| 0.06% | 0.07% | $391,319 | 8,772 | $452,460 | 8,772 | 00.00% | Unchanged |
