 PRAXIS PRECISION MEDICINES IPRAX |
| 10.23% | 12.82% | $681.6M | 2.0M | $656.0M | 2.0M | 00.00% | Unchanged |
| SSPYRE THERAPEUTICS INCSYRE |
| 5.76% | 3.73% | $383.5M | 4.3M | $190.8M | 3.8M | +536,271+14.17% | Add |
 CELCUITY INCCELC |
| 5.02% | 6.97% | $334.5M | 3.2M | $356.9M | 3.1M | +70,000+2.24% | Add |
| AASCENDIS PHARMA A/S SPONSORED ADRASND |
| 4.66% | 6.84% | $310.4M | 1.2M | $350.3M | 1.5M | -367,700-24.01% | Reduce |
 RHYTHM PHARMACEUTICALS INCRYTM |
| 4.31% | 4.03% | $287.2M | 2.6M | $206.4M | 2.4M | +212,500+8.95% | Add |
 ROIVANT SCIENCES LTDROIV |
| 4.3% | 4.48% | $286.1M | 8.1M | $229.5M | 8.3M | -200,000-2.41% | Reduce |
 RELAY THERAPEUTICS INCRLAY |
| 3.96% | 1.9% | $263.9M | 14.1M | $97.0M | 9.8M | +4.4M+44.66% | Add |
| TTRAVERE THERAPEUTICS INCTVTX |
| 3.2% | 2.4% | $213.2M | 3.8M | $123.1M | 4.1M | -389,977-9.41% | Reduce |
| KKARDIGAN INCKARD |
| 2.94% | — | $195.6M | 8.2M | $0 | 0 | +8.2M | New Buy |
| NNUVALENT INCNUVL |
| 2.93% | 3.16% | $195.2M | 1.6M | $161.9M | 1.6M | 00.00% | Unchanged |
 EDGEWISE THERAPEUTICS INCEWTX |
| 2.67% | 2.72% | $177.7M | 4.4M | $139.4M | 4.4M | -50,000-1.13% | Reduce |
 APOGEE THERAPEUTICS INCAPGE |
| 2.61% | 2.53% | $173.6M | 1.3M | $129.7M | 1.5M | -232,271-15.08% | Reduce |
| AAMYLYX PHARMACEUTICALS INCAMLX |
| 2.25% | 2.25% | $149.7M | 8.3M | $115.2M | 8.3M | +50,000+0.60% | Add |
 MEIRAGTX HLDGS PLCMGTX |
| 2.19% | 1.75% | $145.7M | 10.8M | $89.3M | 10.3M | +460,555+4.46% | Add |
| OORUKA THERAPEUTICS INC COMORKA |
| 1.92% | 1.34% | $128.0M | 1.3M | $68.4M | 1.4M | -50,438-3.61% | Reduce |
 INHIBRX BIOSCIENCES INCINBX |
| 1.85% | 1.9% | $123.0M | 1.3M | $97.0M | 1.4M | -144,944-10.05% | Reduce |
| PPROTAGONIST THERAPEUTICS INCPTGX |
| 1.81% | 2.54% | $120.4M | 981,879 | $129.7M | 1.2M | -249,000-20.23% | Reduce |
 SOLID BIOSCIENCES INCSLDB |
| 1.79% | 1.68% | $118.9M | 11.9M | $85.7M | 11.9M | 00.00% | Unchanged |
 ZYMEWORKS INCZYME |
| 1.64% | 1.72% | $109.3M | 4.2M | $87.9M | 3.5M | +672,875+19.17% | Add |
| TTANGO THERAPEUTICS INCTNGX |
| 1.58% | 0.33% | $105.6M | 3.4M | $16.9M | 808,153 | +2.6M+317.87% | Add |
 IMMATICS N.VIMTX |
| 1.58% | 2% | $105.2M | 10.4M | $102.2M | 10.4M | 00.00% | Unchanged |
 NURIX THERAPEUTICS INCNRIX |
| 1.57% | 1.12% | $104.8M | 4.3M | $57.5M | 3.7M | +609,545+16.43% | Add |
 BIOCRYST PHARMACEUTICALS INCBCRX |
| 1.55% | 1.38% | $103.1M | 10.3M | $70.8M | 7.4M | +2.9M+38.67% | Add |
| RREVOLUTION MEDICINES INC COMRVMD |
| 1.48% | 0.49% | $98.8M | 527,600 | $25.1M | 258,600 | +269,000+104.02% | Add |
| AAVALYN PHARMACEUTICALS INCAVLN |
| 1.32% | — | $88.1M | 2.7M | $0 | 0 | +2.7M | New Buy |
 MODERNA INCMRNA |
| 1.05% | 0.99% | $70.0M | 1.0M | $50.8M | 1.0M | 00.00% | Unchanged |
| DDYNE THERAPEUTICS INCDYN |
| 0.9% | 1.65% | $59.7M | 2.7M | $84.6M | 4.7M | -2.0M-42.40% | Reduce |
 BIOGEN INCBIIB |
| 0.9% | — | $59.7M | 276,173 | $0 | 0 | +276,173 | New Buy |
| IIMMUNOVANT INCIMVT |
| 0.79% | 0.78% | $52.3M | 1.4M | $39.7M | 1.6M | -240,000-15.02% | Reduce |
 UNITEDHEALTH GROUP INCUNH |
| 0.73% | — | $48.5M | 116,806 | $0 | 0 | +116,806 | New Buy |
| SSTATE STREET SPDR S&P BIOTECH ETFXBI |
| 0.71% | — | $47.5M | 300,000 | $0 | 0 | +300,000 | New Buy |
 IONIS PHARMACEUTICALS INCIONS |
| 0.67% | 0.74% | $44.9M | 566,000 | $37.8M | 504,000 | +62,000+12.30% | Add |
| SSUTRO BIOPHARMA INCSTRO |
| 0.65% | 0.35% | $43.3M | 1.3M | $17.8M | 715,307 | +589,539+82.42% | Add |
| AALTO NEUROSCIENCE INC COM SHSANRO |
| 0.64% | 0.88% | $42.5M | 1.6M | $45.2M | 2.0M | -400,000-19.90% | Reduce |
 JAZZ PHARMACEUTICALS PLCJAZZ |
| 0.61% | 0.63% | $41.0M | 170,000 | $32.1M | 170,000 | 00.00% | Unchanged |
 CORVUS PHARMACEUTICALS ICRVS |
| 0.6% | 0.66% | $39.9M | 2.7M | $33.5M | 2.3M | +375,000+16.36% | Add |
| SSIONNA THERAPEUTICS INCSION |
| 0.6% | 0.52% | $39.8M | 905,000 | $26.4M | 658,439 | +246,561+37.45% | Add |
 CYTOMX THERAPEUTICS INC.CTMX |
| 0.59% | 0.93% | $39.1M | 10.4M | $47.5M | 10.1M | +340,361+3.37% | Add |
| AARTIVION INCAORT |
| 0.59% | 1.17% | $39.0M | 1.7M | $60.0M | 1.6M | +100,000+6.11% | Add |
| XX4 Pharmaceuticals IncXFOR |
| 0.56% | 0.54% | $37.0M | 7.9M | $27.8M | 6.7M | +1.2M+17.75% | Add |
| CCAPRICOR THERAPEUTICS INC COM NEWCAPR |
| 0.54% | — | $36.1M | 1.5M | $0 | 0 | +1.5M | New Buy |
| CCORCEPT THERAPEUTICS INCCORT |
| 0.52% | 0.04% | $34.6M | 398,385 | $2.0M | 50,000 | +348,385+696.77% | Add |
| RREPLIGEN CORPRGEN |
| 0.51% | 0.65% | $33.9M | 248,212 | $33.1M | 280,541 | -32,329-11.52% | Reduce |
| AANTERIS TECHNOLOGIES GLOBAL COMAVR |
| 0.51% | 0.37% | $33.7M | 3.4M | $19.0M | 3.4M | 00.00% | Unchanged |
| RRAPPORT THERAPEUTICS INCRAPP |
| 0.48% | 0.41% | $32.2M | 773,342 | $21.1M | 673,923 | +99,419+14.75% | Add |
| DDAMORA THERAPEUTICS INCDMRA |
| 0.48% | 0.62% | $31.8M | 1.2M | $31.7M | 1.2M | 00.00% | Unchanged |
| CCHARLES RIV LABS INTL INCCRL |
| 0.48% | — | $31.8M | 140,000 | $0 | 0 | +140,000 | New Buy |
 AXSOME THERAPEUTICS INC.AXSM |
| 0.44% | 0.5% | $29.0M | 118,450 | $25.3M | 149,950 | -31,500-21.01% | Reduce |
| EEYEPOINT INCEYPT |
| 0.43% | — | $28.6M | 2.0M | $0 | 0 | +2.0M | New Buy |
 DBV TECHNOLOGIES S ADBVT |
| 0.41% | 0.39% | $27.1M | 1.7M | $20.1M | 964,391 | +688,959+71.44% | Add |
