 AMGEN INC COMAMGN |
| 7.15% | 7.17% | $21.3M | 79,246 | $21.3M | 79,246 | 00.00% | Unchanged |
 INCYTE CORPINCY |
| 6.96% | 6.97% | $20.7M | 358,454 | $20.7M | 358,454 | 00.00% | Unchanged |
| GGILEAD SCIENCES INC COMGILD |
| 5.88% | 5.9% | $17.5M | 233,584 | $17.5M | 233,584 | 00.00% | Unchanged |
| IINTRA-CELLULAR THERAPIES INCITCIEUR |
| 5.56% | 5.57% | $16.5M | 317,856 | $16.5M | 317,856 | 00.00% | Unchanged |
 BIOMARIN PHARMACEUTICAL INCBMRN |
| 4.57% | 4.58% | $13.6M | 153,656 | $13.6M | 153,656 | 00.00% | Unchanged |
 SUPERNUS PHARMACEUTICALSSUPN |
| 3.95% | 3.96% | $11.8M | 426,500 | $11.8M | 426,500 | 00.00% | Unchanged |
| VVERA THERAPEUTICS INCVERA |
| 3.49% | 3.5% | $10.4M | 758,355 | $10.4M | 758,355 | 00.00% | Unchanged |
 BIOGEN INCBIIB |
| 3.47% | 3.48% | $10.3M | 40,200 | $10.3M | 40,200 | 00.00% | Unchanged |
 HARMONY BIOSCIENCES HLDGS INHRMY |
| 3.46% | 3.47% | $10.3M | 314,500 | $10.3M | 314,500 | 00.00% | Unchanged |
| MMIRATI THERAPEUTICS, INC. |
| 3.16% | 3.17% | $9.4M | 216,000 | $9.4M | 216,000 | 00.00% | Unchanged |
| UULTRAGENYX PHARMACEUTICAL INRARE |
| 2.99% | 3% | $8.9M | 250,052 | $8.9M | 250,052 | 00.00% | Unchanged |
 UNIQURE NVQURE |
| 2.8% | 2.81% | $8.3M | 1.2M | $8.3M | 1.2M | 00.00% | Unchanged |
 AURINIA PHARMACEUTICALS INCAUPH |
| 2.71% | 2.72% | $8.1M | 1.0M | $8.1M | 1.0M | 00.00% | Unchanged |
 UNITED THERAPEUTICS CORP DELUTHR |
| 2.57% | 2.58% | $7.7M | 33,959 | $7.7M | 33,959 | 00.00% | Unchanged |
 VERTEX PHARMACEUTICALS INCVRTX |
| 2.45% | 2.46% | $7.3M | 21,000 | $7.3M | 21,000 | 00.00% | Unchanged |
 REGENERON PHARMACEUTICALSREGN |
| 2.44% | 2.45% | $7.3M | 8,847 | $7.3M | 8,847 | 00.00% | Unchanged |
 ILLUMINA INCILMN |
| 2.33% | 2.34% | $6.9M | 50,500 | $6.9M | 50,500 | 00.00% | Unchanged |
 ALNYLAM PHARMACEUTICALS INCALNY |
| 2.19% | 2.2% | $6.5M | 36,800 | $6.5M | 36,800 | 00.00% | Unchanged |
| AAMYLYX PHARMACEUTICALS INCAMLX |
| 1.81% | 1.82% | $5.4M | 295,000 | $5.4M | 295,000 | 00.00% | Unchanged |
 KRYSTAL BIOTECH INCKRYS |
| 1.8% | 1.8% | $5.3M | 46,092 | $5.3M | 46,092 | 00.00% | Unchanged |
| KKARUNA THERAPEUTICS INC |
| 1.73% | 1.74% | $5.2M | 30,500 | $5.2M | 30,500 | 00.00% | Unchanged |
 AXSOME THERAPEUTICS INC.AXSM |
| 1.37% | 1.37% | $4.1M | 58,300 | $4.1M | 58,300 | 00.00% | Unchanged |
| EERASCA INCERAS |
| 1.27% | 1.28% | $3.8M | 1.9M | $3.8M | 1.9M | 00.00% | Unchanged |
| AACADIA PHARMACEUTICALS INC COMACAD |
| 1.26% | 1.26% | $3.7M | 179,702 | $3.7M | 179,702 | 00.00% | Unchanged |
| RREVANCE THERAPEUTICS INC |
| 1.11% | 1.11% | $3.3M | 288,726 | $3.3M | 288,726 | 00.00% | Unchanged |
 NEUROCRINE BIOSCIENCES INCNBIX |
| 1.09% | 1.09% | $3.2M | 28,877 | $3.2M | 28,877 | 00.00% | Unchanged |
 SAREPTA THERAPEUTICS INCSRPT |
| 1.09% | 1.09% | $3.2M | 26,700 | $3.2M | 26,700 | 00.00% | Unchanged |
 ROCKET PHARMACEUTICALS INC COMRCKT |
| 1.07% | 1.08% | $3.2M | 156,000 | $3.2M | 156,000 | 00.00% | Unchanged |
 DENALI THERAPEUTICS INCDNLI |
| 1.07% | 1.07% | $3.2M | 154,000 | $3.2M | 154,000 | 00.00% | Unchanged |
 ASTRAZENECA PLCAZN |
| 1.06% | 1.06% | $3.1M | 46,500 | $3.1M | 46,500 | 00.00% | Unchanged |
 XENON PHARMACEUTICALS INCXENE |
| 1.05% | 1.05% | $3.1M | 91,500 | $3.1M | 91,500 | 00.00% | Unchanged |
 CYTOKINETICS INCCYTK |
| 1.03% | 0.37% | $3.1M | 37,000 | $1.1M | 37,000 | 00.00% | Unchanged |
 CRISPR THERAPEUTICSCRSP |
| 0.96% | 0.96% | $2.9M | 63,000 | $2.9M | 63,000 | 00.00% | Unchanged |
 MADRIGAL PHARMACEUTICALS INCMDGL |
| 0.9% | 0.9% | $2.7M | 18,300 | $2.7M | 18,300 | 00.00% | Unchanged |
| LLEGEND BIOTECH CORPLEGN |
| 0.86% | 0.86% | $2.6M | 38,000 | $2.6M | 38,000 | 00.00% | Unchanged |
 HALOZYME THERAPEUTICS INCHALO |
| 0.8% | 0.8% | $2.4M | 62,200 | $2.4M | 62,200 | 00.00% | Unchanged |
| MMARINUS PHARMACEUTICALS INC |
| 0.79% | 0.79% | $2.3M | 290,000 | $2.3M | 290,000 | 00.00% | Unchanged |
| BBEONE MEDICINES LTDONC |
| 0.77% | 0.77% | $2.3M | 12,700 | $2.3M | 12,700 | 00.00% | Unchanged |
 JAZZ PHARMACEUTICALS PLCJAZZ |
| 0.75% | 0.75% | $2.2M | 17,200 | $2.2M | 17,200 | 00.00% | Unchanged |
| MMIRUM PHARMACEUTICALS INCMIRM |
| 0.72% | 0.72% | $2.1M | 67,500 | $2.1M | 67,500 | 00.00% | Unchanged |
| IIOVANCE BIOTHERAPEUTICS INCIOVA |
| 0.68% | 0.68% | $2.0M | 445,000 | $2.0M | 445,000 | 00.00% | Unchanged |
 IONIS PHARMACEUTICALS INCIONS |
| 0.65% | 0.66% | $1.9M | 43,000 | $1.9M | 43,000 | 00.00% | Unchanged |
| ZZAI LAB LIMITED ADS EACH REP 10 ORD SHSZLAB |
| 0.64% | 0.65% | $1.9M | 78,958 | $1.9M | 78,958 | 00.00% | Unchanged |
| GGENMAB A/S SPONSORED ADSGMAB |
| 0.52% | 0.53% | $1.6M | 44,300 | $1.6M | 44,300 | 00.00% | Unchanged |
| CCELLDEX THERAPEUTICS INC NEWCLDX |
| 0.44% | 0.45% | $1.3M | 48,099 | $1.3M | 48,099 | 00.00% | Unchanged |
| DDYNE THERAPEUTICS INCDYN |
| 0.41% | 0.41% | $1.2M | 137,751 | $1.2M | 137,751 | 00.00% | Unchanged |
| NNOVOCURE LTDNVCR |
| 0.4% | 0.4% | $1.2M | 74,000 | $1.2M | 74,000 | 00.00% | Unchanged |
| AAMICUS THERAPEUTIC COMAM6 |
| 0.37% | 0.37% | $1.1M | 90,000 | $1.1M | 90,000 | 00.00% | Unchanged |
 GUARDANT HEALTH INCGH |
| 0.36% | 0.36% | $1.1M | 36,500 | $1.1M | 36,500 | 00.00% | Unchanged |
 INSMED INCINSM |
| 0.34% | 0.34% | $1.0M | 40,100 | $1.0M | 40,100 | 00.00% | Unchanged |
